Internal Medicine Videos & books

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Correct Answer -D Leukoerythroblastosis refers to the presence of immature nucleated RBCs, immature white blood cells, and megakaryocyte fragments on the peripheral blood smear. It occur due to bone marrow infiltration. When marrow infiltration causes anemia or pancytopenia, it is referred to as myelophthisic anemia. The most common cause of myelophthisis includes metastatic carcinoma of the lung, breast, or prostate. Other causes include hematologic malignand (leukemia, lymphoma), infections (tuberculosis, fungi), and metabolic diseases (Gauchl disease, Niemann-Pick disease). Thalassemia is not associated with leukoerythroblasto. Ref: CURRENT Diagnosis & Treatment in Family Medicine, 3rd Edition, Chapter 31

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Correct Answer -C The major factor controlling the contraction of the gallbladder is the hormone cholecystokinin (CCK), which is released from the duodenal mucosa (I cells) in response to the ingestion of fats and amino acids Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 2616

Bromsulphalein test (BSP) is the diagnostic test for Dubin-Johnson Syndrome. Biliary excretion of numerous anionic compounds such as Bromsulphalein (BSP) is compromised in Dubin-Johnson Syndrome (DJS). In this test, BSP is administered as IV bolus and its clearance from plasma is determined. BSP levels show a characteristic rise in patients with DJS after 90 minutes of injection, due to reflux of conjugated BSP into the circulation from the hepatocyte. Ref: Davidson's principles and practice of Medicine, 20th Edition, Chapter 23, Page 945; Harrison's Principles of Internal Medicine, 16th Edition, Page 1821; Digestive Diseases and Sciences Vol/17 numbers 6.

orrect Answer -C The definitive diagnosis of PNH is based on the demonstration that a substantial proportion of the patient's red cells have an increased susceptibility to complement (C), due to the deficiency on their surface of proteins (particularly CD59 and CD55). Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 884

Correct Answer-D Leukoerythroblastosis refers to the presence of immature nucleated RBCs, immature white blood cells, and megakaryocyte fragments on the peripheral blood smear. It occur due to bone marrow infiltration. When marrow infiltration causes anemia or pancytopenia, it is referred to as myelophthisic anemia. The most common cause of myelophthisis includes metastatic carcinoma of the lung, breast, or prostate. Other causes include hematologic malignancies (leukemia, lymphoma), infections (tuberculosis, fungi), and metabolic diseases (Gaucher disease, Niemann-Pick disease). Thalassemia is not associated with leukoerythroblastosis. Ref: CURRENT Diagnosis & Treatment in Family Medicine, 3rd Edition, Chapter 31