Internal Medicine Videos & books

Correct Answer -B This patient is showing signs and symptoms of Myasthenia gravis. Edrophonium test is the most useful test in making a diagnosis of this condition because of the rapid onset and short duration of its effect. This test is considered to be positive if there is any improvement in the weakness of this patient after administration of edrophonium. Other diagnostic tests used for diagnosing myasthenia gravis are: • Acetyl choline receptor antibodies: Presence of this antibodies is virtually diagnostic of MG, but a negative test does not exclude the disease. ◦ Rapid nerve stimulation test: In this test electric shocks are delivered at a rate of 2 or 3 per second to the appropriate nerves, and action potentials are recorded from the muscles. In these patients there is a rapid reduction of >10-15% in the amplitude of the evoked responses. Ref: Drachman D.B. (2012). Chapter 386. Myasthenia Gravis and Other Diseases of the Neuromuscular Junction. In D.L. Longo, A.S. Fauci, D.L. Kasper,S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.

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Individuals with sickle cell trait (hemoglobin genotype AS) are resistant to the lethal effects of Plasmodium falciparum infection. This is because the sickle cell traits prevents the development of high parasitemia, probably partly as a result of parasitized red cells sickling in the circulation and being removed by the spleen before they can develop into schizonts Absence of RBC Duffy antigen confers resistance to P. Vivax. Ref: Harrison's 17th ed chapter 213 ; Essentials of clinical immunology by Helen Chapel, Man;e. Haeney, Siraj Misbah, 5th edition, Page 48; Lecture Notes: Tropical Medicine edited by G. V. Gill, Nick Beeching, 2011, Page 62.

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Correct Answer-A Ans. A. CLL evolving into aggressive lymphoma Richter's transformation or Richter's syndrome is a complication of B cell chronic lymphocytic leukemia (CLL) or hairy cell leukemia (HCL) in which the leukemia changes into a fast-growing diffuse large B cell lymphoma

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Diagnose on the basis of given pictures ???