Pathology videos & books

Correct Answer - D Ans. is 'd' i.e., Seen in teratoma o Psammoma bodies represent a process of dystrophic calcification. o Single necrotic cells may constitute seed crystals that become encrusted by the mineral deposits. The progressive acquisition of outer layers may create lamellated configurations, called psammoma bodies because of their resemblance to grains of sand. o Psammoma bodies are seen in : papillary cancer of thyroid, meningioma, papillary serous cystadenocarcinoma of ovary.

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Ans. is 'b' i.e., Spongiform change in brain o The classic histologic appearance in Creutzfeldt-Jakob disease is spongiform change in the gray matter : in all six cortical layers in the cerebral cortex or with diffuse involvement of the cerebellar molecular layer. These vacuoles appear glassy or eosinophilic and may coalesce. Neuronal loss and gliosis are also seen.

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Correct Answer - A Acute promyelocytic leukemia [Ref. Harrison 16' 11 /e p 636] Disseminated intravascular coagulation is associated with promyelocytic leukemia Acute promyelocytic leukemia (AML-M3 ) constitutes 5-10% of all cases of AML The leukemic cells of these type of anemia are hypergranular. Granules of these leukemic cells (promyelocytes) contain thromboplastin like material resulting in widespread disseminated intravascular coagulation. Also know Majority of M3 cases demonstrate a reciprocal translocation involving chromosome 15 and 17, t (15 ; 17)

Correct Answer-D Answer-D. Bone marrow Dutcher bodies, which are attributed to immunoglobulin filled cytoplasm invaginating into the nucleus creating the appearance of an intranuclear inclusion. Dutcher bodies are described as intranuclear inclusions in patients with Waldenstrom's macroglobulinemia The inclusions are positive on a periodic acid-Schiff reaction and were present in the cytoplasm as well as the nucleus. They identified the inclusions as glycoprotein and postulated that they might be chemically identical to the macroglobulin in the plasma.

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Correct Answer: a) Epstein-Barr virus --- 💡 Why others are incorrect: b) CMV – Can cause mononucleosis-like illness, but Monospot is negative and atypical lymphocytes are less prominent. c) Streptococcus pyogenes – Causes bacterial pharyngitis, no atypical lymphocytes, no positive Monospot. d) HIV – May cause acute retroviral syndrome, but lacks Monospot positivity and typical triad. e) Toxoplasma gondii – Can mimic mono, but Monospot negative, and rare in immunocompetent hosts.

A 19-year-old college student presents with fatigue and sore throat. His peripheral smear shows atypical lymphocytes. His Monospot test is positive. What is the likely causative organism? Comment upon this. Try without options. We have discussed it so many times.

A 19-year-old college student presents with fatigue and sore throat. His peripheral smear shows atypical lymphocytes. His Monospot test is positive. What is the likely causative organism? Comment upon this. Try without options. We have discussed it so many times.